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Anti-inflammatory foods, minus the wishful thinking

Nathaniel SzerezlaFounder of Natural Me, trained chef, CNM-certified naturopath8 min read
Turmeric Flore d'Amérique (1843-1846) Étienne, a public domain botanical plate.

The short answer

The best-evidenced anti-inflammatory foods are oily fish, extra virgin olive oil, leafy greens, berries and nuts, which together form the Mediterranean pattern. Turmeric works only when paired with fat and black pepper, since curcumin is poorly absorbed on its own. Pattern matters far more than any single food.

Anti-inflammatory is the most abused phrase in food marketing, and it is a shame, because underneath the noise there is a genuinely well-evidenced dietary pattern. The problem is that the pattern is boring to sell and the individual ingredients are not.

I cook for a living and trained in naturopathic nutrition, and the thing that consistently surprises people is how much the preparation decides the outcome. You can buy every item on this list and get very little from most of them.

Chronic versus acute

Acute inflammation is the swelling around a sprained ankle. It is useful and it resolves. Chronic low-grade inflammation is a persistent background state associated with heart disease, type 2 diabetes and several other long-term conditions.

Food influences the second one, slowly, as a pattern. No meal reduces inflammation the way ibuprofen does, and anything promising that is selling something.

The list, with the cooking that makes it work

Extra virgin olive oil

The single best-evidenced item here. It contains oleocanthal, a compound that acts on the same pathway as ibuprofen, though far more weakly. The peppery catch at the back of your throat from a good oil is literally oleocanthal. A bland oil has less.

Buy it in dark glass and use it as your default fat. The idea that you cannot cook with it is largely a myth at normal domestic temperatures. Its smoke point is well above most pan cooking.

Turmeric, but only prepared correctly

Curcumin has genuine anti-inflammatory activity and terrible bioavailability. On its own, very little reaches your bloodstream.

Two things change that substantially: fat, because curcumin is fat-soluble, and piperine from black pepper, which slows its breakdown considerably. This is why traditional preparations bloom turmeric in oil with pepper, and why a turmeric capsule taken with water is close to pointless.

A turmeric latte made with fat and pepper is medicine-adjacent. Turmeric in water is decoration.

Preparation is not a detail here

Oily fish

EPA and DHA are directly anti-inflammatory, and the evidence is strong. Salmon, mackerel, sardines, herring. Twice a week. Tinned counts and costs a fraction of fresh.

Leafy greens and cruciferous vegetables

Polyphenols, sulforaphane, folate, magnesium. Do not boil them to death. Water-soluble compounds leave with the water. Steam, sauté, or roast.

Berries

Anthocyanins, the compounds giving them their colour, have solid anti-inflammatory evidence. Frozen are nutritionally comparable to fresh and considerably cheaper, which matters if this is going to be a habit rather than a phase.

Nuts, especially walnuts

Omega-3, vitamin E, polyphenols. A handful daily is the quantity used in most of the research.

What drives inflammation up

Refined seed oils in excess
The issue is the ratio. Very high omega-6 relative to omega-3 shifts the balance. This is about proportion, not about seed oils being poison.
Refined sugar
Promotes the formation of advanced glycation end products, which are inflammatory.
Ultra-processed food
Consistently associated with inflammatory markers. See what ultra-processed actually means.
Excess alcohol
Directly inflammatory to the gut lining and the liver.

How I would actually eat this

None of this is exotic and none of it is expensive. That is rather the point. The pattern is what carries the evidence, and a pattern has to be affordable to persist.

Common questions

What are the best anti-inflammatory foods?

Extra virgin olive oil, oily fish, leafy greens, berries and nuts have the strongest evidence, and together they form the Mediterranean pattern. The overall pattern matters considerably more than any individual food.

Does turmeric actually reduce inflammation?

Curcumin has genuine anti-inflammatory activity but is very poorly absorbed on its own. It needs fat, because it is fat-soluble, and black pepper, which slows its breakdown. Turmeric taken in water does very little.

Can you cook with extra virgin olive oil?

Yes. The claim that it is unsuitable for cooking is largely a myth at normal domestic temperatures, as its smoke point sits above most pan cooking. Use it as your default fat.

Are seed oils inflammatory?

The issue is proportion rather than poison. A very high intake of omega-6 relative to omega-3 shifts the balance in an inflammatory direction. Raising omega-3 intake matters as much as lowering omega-6.

How long do anti-inflammatory foods take to work?

Inflammatory markers can shift within weeks of consistent dietary change, but the health outcomes associated with lower chronic inflammation accrue over years. This is a pattern to adopt, not a protocol to complete.

Food as medicine, written plainly.